Wednesday's Premier League fixture between Arsenal and Manchester City at the Etihad Stadium has been cancelled as a precautionary measure after coronavirus outbreak.
Arsenal said players will be isolated for 14 days after coming into contact with the owner of Greek club Olympiakos, who has tested positive for COVID-19.
"We are strictly following the government guidelines which recommend that anyone coming into close contact with someone with the virus should self-isolate at home for 14 days from the last time they had contact," an Arsenal statement said.
"As a result, the players are unavailable for tonight's (Wednesday's) match against Manchester City and the Premier League has decided the game should be postponed."
Olympiakos owner Evangelos Marinakis was tested positive for coronavirus and a number of players met him immediately following the Europa league clash between Olympiakos and Arsenal.
The first postponement in the Premier League, which has a worldwide following of billions of TV viewers, comes after UEFA's Champions League and Europa League were both forced to arrange matches behind closed doors.
Football's top-flight Serie A and all other sports have been put on hold in Italy, which is under national lockdown as virus cases soar.
Matches in the top two divisions in Spain and France will be played behind closed doors for at least the next two weeks, officials announced Tuesday.
In Asia, football has been suspended in China, South Korea and Japan, and the AFC Champions League schedule heavily disrupted.