Toronto: Women who have more kids may age slowly, suggests a new study that found the number of children born to a woman influences the rate at which her body ages.
Researchers at Simon Fraser University in Canada found that women who give birth to more surviving children exhibited longer telomeres.
Telomeres are the protective tips found at the end of each DNA strand and are indicative of cellular ageing. Longer telomeres are integral to cell replication and are associated with longevity.
The study assessed the number of children born to 75 women from two neighbouring indigenous rural Guatemalan
communities, and their telomere lengths.
The participants’ telomere lengths were measured at two time points 13 years apart, through salivary specimens and
buccal swabs. This was the first study to examine the direct association between the number of children and telomere shortening in humans over time.
According to the researchers, the study findings contradict life history theory which predicts that producing a higher number of offspring accelerates the pace of biological ageing.
“The slower pace of telomere shortening found in the study participants who have more children however, may be attributed to the dramatic increase in oestrogen, a hormone produced during pregnancy,” said Pablo Nepomnaschy, who led the study.
“Oestrogen functions as a potent antioxidant that protects cells against telomere shortening,” he added. The social environment that the study participants live in may also influence the relationship between their reproductive efforts and the pace of ageing.
“The women we followed over the course of the study were from natural fertility populations where mothers who bear numerous children receive more social support from their relatives and friends,” Nepomnaschy said.
“Greater support leads to an increase in the amount of metabolic energy that can be allocated to tissue maintenance,
thereby slowing down the process of ageing,” he added. The findings were published in the journal PLoS ONE.