Fasting diets could harm future generations: Study

Washington: A new study from the University of East Anglia (UEA) has found that fasting diets could impact the health of future generations. The findings of the study were published in the journal 'Proceedings of the Royal Society B'.

Fasting diets have risen in popularity in recent years, however little is known about the long-term impact of these diets, particularly for future generations. This research revealed that reduced food intake in roundworms (Caenorhabditis elegans) has a detrimental effect on three generations of offspring — particularly when those descendants have access to unlimited food.

Lead researcher Dr Edward Ivimey-Cook, from UEA's School of Biological Sciences, said, "We know that reduced food intake increases the lifespan in many animals and can potentially improve health in humans. However, little is known about the long-term effects of reduced food intake, including time-limited fasting, on distant descendants." "We wanted to find out more about the potential long-term impact of fasting diets," Dr Ivimey-Cook added.

The team investigated the effect of time-limited fasting on lifespan and reproduction in roundworms and across three generations of their descendants. They studied more than 2,500 worms split across four generations. The first generation of worms was placed in one of four environments, including being able to eat as much as they liked, and being on a fasting diet.

Four generations of offspring from these parents were then placed onto either full-feeding or fasting diets. The team then assessed the effects of different scenarios on the reproduction and longevity of future generations. These included what happens when great grandparents fast, but future generations are able to eat as much as they like, and cumulative fasting for four generations.

Dr Ivimey-Cook said, "We looked at what happens in roundworms. Unlike us, they're transparent, about 1mm long and live in the soil." "They don't have bones, a heart, or a circulatory system. But they're a classic model organism for studying the ageing process in biology because they do share many genes and molecular pathways that control development with humans," Dr Ivimey-Cook further stated.

"They are also really useful because they have a short life cycle of only two weeks, so we can study their development and that of generations of their offspring in a short amount of time. Doing a similar study across humans could take a century or more," Dr Ivimey-Cook noted.

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