Chinese researchers have identified a neuroimaging biomarker that can facilitate the early detection of Alzheimer's disease (AD).
AD is a chronic neurodegenerative disease characterised by progressive dementia. Neuroimaging techniques such as magnetic resonance imaging (MRI) can help diagnose AD. Accurate data-driven methods that can classify and characterise the neural features of AD would be powerful clinical tools.
Researchers from the Institute of Automation of the Chinese Academy of Sciences and other collaborators found that hippocampal radiomic features can be a promising personalised biomarker for AD.
In their search for suitable biomarkers, researchers proposed a novel hippocampal radiomic biomarker derived from structural MRI and systematically validated its reliability using neuroimaging data from over 1,900 individuals, including more than 700 located at six sites in China and around 1,200 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset.
The study showed that hippocampal radiomic features are related to the clinical features and changes in cognition ability. Long-term follow-up data in some hospitals demonstrated that the markers could be used to track the progression of the disease in high-risk subjects. The research was published in the journal Science Bulletin.
