Washington Scientists, led by an Indianorigin researcher, claim to have found a certain cellular pathway, which is linked to obesity- related disorders like diabetes, heart disease and fatty liver disease.
Tapan Chatterjee and colle
agues at the University of Cincinnati, says, its findings could lead to a potential molecular target for metabolic diseases in humans.
They found that genetically alt39 deletingalt39 the enzyme histone deacetylase 9 ( HDAC9) completely protected mice against the health consequences of high- fat feeding, like elevated blood sugar, cholesterol levels and fatty liver disease.
Chatterjee says, HDAC9 has been found to lead to obesity- induced body fat dysfunction. ” Failure of fat cells to differentiate and properly store excess calories in obesity is associated with adipose tissue ( fat) inflammation, fatty liver disease, insulin resistance, diabetes and increased cardiovascular diseases,” he said.
” We know that dysfunctional fat tissue is the underlying culprit in obesity- related diseases. Caloric intake promotes HDAC9 down- regulation to allow the conversion of precursor fat cells to functional fat cells, capable of efficiently storing excess calories for future use and also maintaining wholebody lipid and glucose stability.
” Unfortunately, during chronic over- feeding, the HDAC9 level is up- regulated in fat tissue, thereby blocking the conversion which leads to adipose tissue dysfunction and the onset of diseases such as diabetes,” Chatterjee added.
