Researchers discover neural circuit that drives physical responses to emotional stress
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Washington: A neural circuit that drives physical responses to emotional stress has been discovered by researchers in a recent study. This circuit could be a key target for treating stress-related disorders such as panic disorder and PTSD.

The circuit begins in deep brain areas, called the dorsal peduncular cortex and the dorsal tenia tecta (DP/DTT), that send stress signals to the hypothalamus, a small region in the brain that controls the body's vital functions. The findings were published in the journal Science.

Emotional stress activates the sympathetic nervous system, which leads to physical responses, such as a rise in blood pressure and body temperature and a faster heart rate. Such responses are thought to be coping mechanisms in humans and many other mammals to boost physical performance in fight-or-flight situations.

But nowadays, when most people rarely encounter such situations, these responses could perhaps have an adverse effect on their health. Excessive stress may cause symptoms such as psychogenic fever, a condition of abnormally high body temperature.

To develop strategies for treating stress-induced symptoms, the neural mechanism underlying physical responses to stress had first to be understood. To this end, a research team led by Professor Kazuhiro Nakamura and Designated Assistant Professor Naoya Kataoka, of the Nagoya University Graduate School of Medicine, conducted a study in which tracers were injected into the brains of a group of rats and the rats were subjected to a stressful event (rat bullying by a dominant rat).

The tracers showed that specifically, the DP/DTT brain areas were highly active when exposed to stress. To further examine the role these brain areas have in stress response, the researchers impaired the areas' connections to the hypothalamus and again exposed the rats to the same stress.

The rats did not exhibit any stress-induced physical response, neither a rise in blood pressure nor body temperature or faster heart rate.

This study demonstrates that the DP/DTT areas together are responsible for sending stress signals to the hypothalamus, and that blocking the DP/DTT-to-hypothalamus circuit can result in a reduction of stress symptoms in rats.

Summing up the research result, Professor Nakamura said, "The DP/DTT are parts of the brain that are involved in processing emotion and stress. The DP/DTT-to-hypothalamus pathway we discovered, therefore, represents a brain mechanism for a 'mind-body connection,' which can be a potential target for treating stress-related disorders such as panic disorder, post-traumatic stress disorder (PTSD) and psychogenic fever."

(To download our E-paper please click here. The publishers permit sharing of the paper's PDF on WhatsApp and other social media platforms.)

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