Washington: Researchers now claim that nitric oxide treatment can be pivotal in the world's fight against SARS-CoV-2, the coronavirus that causes COVID-19.
Nitric oxide is an antimicrobial and anti-inflammatory molecule with key roles in pulmonary vascular function in the context of viral infections and other pulmonary diseases.
In SARS-CoV-1 infection, which led to the outbreak of SARS (severe acute respiratory syndrome) in 2003, nitric oxide inhibited viral replication by cytotoxic reactions through intermediates such as peroxynitrite, the study, published in the journal Nitric Oxide, reported.
"Nitric oxide plays key roles in maintaining normal vascular function and regulating inflammatory cascades that contribute to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)," said study researcher Adam Friedman from George Washington University in the US.
"Interventions that are protective against ALI and ARDS can play a critical role for patients and health systems during the pandemic," Friedman added.
According to the researchers, coronaviruses are RNA viruses that primarily infect birds or livestock but can mutate to be highly infectious and lethal in humans. There is currently no registered treatment or vaccine for COVID-19.
The absence of a specific treatment and the high mortality rate of the virus dictate an urgent need for therapeutics that may control the replication and rapid spread of the virus.
For the results, the research team reviewed data from between 1993 and 2020 on the pathogenesis of coronaviruses and the use of nitric oxide as a treatment for respiratory illness.
The authors highlighted the potential for inhaled nitric oxide contributing to better clinical outcomes and alleviating the rapidly rising strain on health care capacity due to COVID-19.
As groups continue to publish more results with their respective nitric oxide platforms, the team recommends that dosing and protocol variations should be examined in evaluating the studies.
"With the emergence of COVID-19 as a pandemic with the ability to overwhelm the body and our health care infrastructure, patients have a pressing need for effective agents that can slow the disease in their bodies and in their communities," Friedman said.
The authors suggest that if nitric oxide's efficacy is illustrated for COVID-19, its use as a treatment can be pivotal in the fight against the pandemic.