Male, female brains operate differently

Washington : Male and female brains operate differently at a molecular level, a new study of a brain region involved in learning and memory, responses to stress, and epilepsy has found, reports PTI.

Many brain disorders vary between the sexes, but how biology and culture contribute to these differences has been unclear. Now researchers at the Northwestern University in US have found an intrinsic biological difference between males and females in the molecular regulation of synapses in the hippocampus.

This provides a scientific reason to believe that female and male brains may respond differently to drugs targeting certain synaptic pathways, researchers said. “The importance of studying sex differences in the brain is about making biology and medicine relevant to everyone, to both men and women,” said Catherine S Woolley, senior author of the study.

Scientists found that a drug called URB-597, which regulates a molecule important in neurotransmitter release, had an effect in females that it did not have in males. While the study was done in rats, it has broad implications for humans because this drug and others like it are currently being tested in clinical trials in humans.

“We don’t know whether this finding will translate to humans or not, but right now people who are investigating endocannabinoids in humans probably are not aware that manipulating these molecules could have different effects in males and females,” Woolley said.

Researchers found that in female brains the drug URB-597 increased the inhibitory effect of a key endocannabinoid in the brain, called anandamide, causing a decrease in the release of neurotransmitters. In male brains, the drug had no effect. The subject of many clinical trials, endocannabinoids are molecules that help regulate the amount of certain neurotransmitters released at synapses, the gap between neurons.

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