Sydney: If you love to include chillies in your diet, you have another healthy reason to do so. According to a study, consumption of hot chillies can prevent overeating via an action on nerves in the stomach, thus curbing obesity in chilli lovers.
Researchers from University of Adelaide discovered that a high-fat diet may impair important hot chilli receptors located in the stomach that signal fullness. The stomach stretches when it is full, which activates nerves in the stomach to tell the body that it has had enough food. “We found that this activation is regulated through hot chilli pepper or TRPV1 receptors in the stomach,” said associate professor Amanda Page from University of Adelaide’s school of medicine.
The team also found that TRPV1 receptors can be disrupted in high fat diet-induced obesity. It is known from previous studies that capsaicin, found in hot chillies, reduces food intake in humans. “We discover that deletion of TRPV1 receptors dampens the response of gastric nerves to stretch – resulting in a delayed feeling of fullness and the consumption of more food,” Page explained. Therefore, part of the effect of capsaicin on food intake may be mediated via the stomach.
“It is exciting that we now know that the consumption of capsaicin may be able to prevent overeating through an action on nerves in the stomach,” added Dr Stephen Kentish, National Health and Medical Research Council (NHMRC) fellow from University of Adelaide. The next stage of research will involve investigation of the mechanisms behind TRPV1 receptor activation with the aim of developing a more palatable therapy.
“We will also do further work to determine why a high-fat diet de-sensitises TRPV1 receptors and investigate if we can reverse the damage,” he concluded. The paper appeared in the journal PLOS ONE.